Written
by: Amber Long, West Bladen High School FFA President
Equine
Metabolic Syndrome
Equine Metabolic Syndrome (EMS), or Insulin
Resistance, is a disorder of carbohydrate metabolism that is usually seen in
overweight, middle-aged horses. It is associated with severe laminitis. These
horses may build up a high level of cortisol. Increased circulating levels of
cortisol increase blood sugar and inhibit the uptake of glucose into cells by
antagonizing the action of insulin. Persistent high blood sugar is known to be
toxic and it is possible that it contributes to laminitis in horses by damaging
the blood vessels in the hoof.
Clinical signs include:
- Laminitis – typically begins in the spring with rapid growth of grass
- General obesity with regional and/or regional adiposity
- Crusty neck, fat deposits around the tail head, sheath and suborbital fossa (hollow above the eyes), occasional subcutaneous masses on the trunk
Resting insulin and blood sugar are the most common
screening tests used to diagnose the metabolic syndrome. If you suspect that
your horse has laminitis due to metabolic syndrome, schedule a physical exam
with your veterinarian. You may also test your hay to determine the
carbohydrate content. Straight alfalfa is not appropriate for these horses.
The goal of treatment is to improve insulin
sensitivity and raise the threshold for laminitis. Metabolic Syndrome can be
managed through diet and exercise.
Equine
Cushing’s Disease
Equine Cushing’s disease is a disorder of the
pituitary gland that results in hormonal imbalances. In affected horses, the
pituitary gland is usually enlarged and overactive as a result of faulty
regulation by the hypothalamus. This disease usually occurs in middle-aged and
geriatric horses.
Clinical signs include:
- A long, wavy hair coat that fails to shed according to normal seasonal patterns
- Excessive sweating
- Lethargy and poor athletic performance
- Chronic recurrent laminitis
- Infertility
- Weight loss
- Muscle wasting, especially along the topline
- Abnormal distribution of fat, with accumulations in the crest of the neck, tail head, sheath, and above the eyes
- Consumption of large volumes of water and passage of large amounts of urine
- Delayed wound healing
- Increased susceptibility to infections
In advanced cases, diagnosis is straightforward.
However, diagnosis of early cases or those with few obvious clinical signs is
more difficult. Two commonly used tests are: the dexamethasone suppression test
and measurement of plasma ACTH concentration.
Managing Cushing’s disease involves both specific
medication to normalize the function of the pituitary gland and supportive care
to address and prevent complications associated with the disease. Management
will be life-long because there is no way to reverse the disease process.
For additional information, visit these articles: Equine Endocrinology: Cushing’s
Disease and Metabolic Syndrome from the American Association of Equine Practitioners,
Insulin resistance in horses from
University of Minnesota Extension, and Management of Equine Cushing’s
Disease and Equine Metabolic Syndrome from the University of Florida.